Yes, we can process and translate PDF files. If you send us your source as a PDF file, we are able to run a manual estimate and pretranslation for you, just as with any other file. We are also able to create terminology resources out of PDF files, such as a translation memory or glossaries.
However, we strongly suggest our clients to provide us with the original files if possible, mainly if layout work is needed. It is difficult (and in certain cases almost impossible) to maintain the multilingual layout 1:1 without the original files, and we need to charge extra for the DTP work needed to deliver proper target layout.
The above applies to PDF files where we can copy text. For scanned PDF files, we can only translate them manually without matching layout elements, such as illustrations, artwork, etc.